Genetic white matter disorders expanded network

GWMD expanded network
Starting with a seed list of 843 genes that are associated or causative of GWMD according to OMIM, we built a protein interactome network based on the principle that physical and functional interacting proteins (to these 843 seed genes) could account for related biological processes and cause similar diseases. We developed a prioritization method that identifies the most likely disease-causing genes associated with each patient's phenotype (standardized in Human Phenotype Ontology (HPO)) using a global protein human interactome network built with functional and physical interactions, represented by 20.146 genes. We applied this prioritization tool to the respective clinical description in HPOs of the 843 proteins associated with GWMD to build a GWMD interactome or expanded network, resulting in 1530 proteins and 18288 interactions.