Insulin mitigates acute ischemia induced atrial fibrillation and sinoatrial node dysfunction ex vivo

Acute atrial ischemia is a well-known cause of postoperative atrial fibrillation (POAF). However, the cellular and electrophysiological mechanisms through which ischemia contributes to the development of POAF are not well understood. Administering insulin 30 minutes before ischemia and during reperfusion with 25 minutes of ischemia greatly reduced the vulnerability to AF.急性心房缺血是术后心房颤动（postoperative atrial fibrillation, POAF）的公认致病诱因。然而，缺血促使POAF发生的细胞与电生理机制尚未得到充分阐明。在缺血前30分钟以及缺血时长25分钟后的再灌注阶段给予胰岛素，可显著降低心房颤动（atrial fibrillation, AF）的易感性。