Transcriptome analysis of Nothapodytes nimmoniana (Graham) Mabb. (Icacinaceae), a plant producing the anti-cancer alkaloid, camptothecin. Nothapodytes nimmoniana

Camptothecin, a monoterpene indole alkaloid, is a potent inhibitor of DNA topoisomerase I. Several semi-synthetic drugs namely topotecan and irinotecan are derived from camptothecin and are in clinical use against ovarian, small lung and refractory ovarian cancers. To analyse CPT biosynthetic pathway in Nothapodytes nimmoniana and relative expression profiles of the CPT pathway genes and CPT accumulation in various tissues