SNP Typing for Association with Multiple Phenotypes from Existing Epidemiologic Data, GWAS in NHLBI cohorts. NHLBI STAMPEED

The goal of STAMPEED is to identify genetic variants related to heart, lung, and blood disorders and their risk factors by utilizing rapidly developing methods of genome-wide association in existing human studies. Data generated by this effort will contribute to knowledge of the underlying biochemical pathways to disease, the interaction of genetic components with each other and with the environment. Results have the potential to identify novel predictors of disease, new therapeutic interventions, prevention strategies and treatments, as well as predictors of response to treatment. STAMPEED is comprised of the following studies: [1] A Genome-wide Association Study for Early-Onset Myocardial Infarction (STAMPEED: MIGen) GWAS of early onset MI and related risk factors in 6,042 Caucasian cases and controls (MIGen). Data are from multiple North American and European studies. [2] Genome-Wide Association Studies of Asthma in Populations of African Descent GWAS of asthma in cases and controls of African ancestry in Barbados (GRAAD study). Approximately 2,000 individuals have genotype and phenotype available. [3] Genome-Wide Association of Platelet Phenotypes GWAS of platelet aggregation phenotypes in response to aspirin therapy. Approximately 3,358 family members of European and African ancestry from the GeneStar study were genotyped and phenotyped. [4] Genome-Wide Association for Loci Influencing CHD and Other Heart, Lung and Blood (STAMPEED: ARIC) GWAS of multiple HLB risk factors, disease correlates and outcomes on a subset of the ARIC study. Sample was approximately 3,600 individuals of African and European ancestry. [5] A Genome-wide Association Study of Childhood Respiratory Outcomes GWAS of childhood asthma and lung function development in Caucasians and Hispanics from the Children Health Study with a focus on assessing gene by environment interaction. Genotype, phenotype and extensive environmental exposure data are available for 3,000 childhood asthma cases and case-parent trios. [6] Whole Genome Association Analysis of Hematopoietic Cell Transplant Outcome GWAS of Graft vs. Host disease, immunological tolerance, airflow obstruction, acute kidney injury, gram-negative bacteremia, invasive fungal disease, CMV infection, disease relapse and mortality. Samples are from hematopoietic stem cell transplant donors and recipients at the Fred Hutchison Cancer Center that are ethnically representative of the population. [7] Genomic Predictors of Arteriosclerosis in Hypertensives GWAS of atherosclerosis and CVD risk factors in hypertensive cases from the GENOA study. Genotypes and phenotypes are available for 3,000 individuals of European and African ancestry. [8] Genome Wide Association for Asthma and Lung Function GWAS of asthma and lung function phenotypes in severe asthma cases and controls for 2,632 individuals of European and African ancestry. [9] Genetics of cardiovascular risk factors in large founder population birth cohort. (STAMPEED: Northern Finland Birth Cohort) GWAS of multiple CVD risk factors, disease correlates and outcomes in the Northern Finnish Birth Cohort, 1966. Approximately 4,500 individuals have both phenotype and genotype data. [10] FHS-SCAN Genome Wide Association Scan for Atherosclerosis Pathway Genes GWAS of atherosclerosis phenotypes in Caucasian participants from the Family Heart Study. Approximately 1,000 Caucasian participants were genotyped. [11] WGA Study to Identify Genetic Variants Associated with CV Events in CHS (STAMPEED: CHS) GWAS of CVD risk factors and outcomes in 4,000 participants of European and African ancestry in the Cardiovascular Health Study. [12] Whole Genome Association for Early Coronary Artery Disease and Related Phenotypes GWAS of early onset coronary artery disease in 1,020 participants from the ADVANCE (Atherosclerotic Disease, Vascular Function, and Genetic Epidemiology) study. Samples were collected through Kaiser and are from cases and controls ethnically representative of the population. [13] Genome-Wide Association Studies in Sickle Cell Anemia and in Centenarians GWAS of selected subphenotypes of sickle cell disease, clinical phenotypes, and a 'global" severity index combined with GWAS of Centenarians from the New England Centenarian Study. Genotype and phenotype are available for approximately 1,800 African American sickle cell patients and 1,000 centenarians of European ancestry and their family members.