ParameciumDB

Paramecia are unicellular eukaryotes of large size (~ 120 micrometers for P aurelia species) that belong to the ciliate phylum. Ciliates, like the Last Eukaryotic Common Ancestor, have the axonemal structure in the form of vibrating cilia that assure locomotion and food capture and are essential for pairing of paramecia of opposite mating types during conjugation (sexual reproduction). Like multicellular eukaryotes, ciliates separate germinal and somatic functions, harbouring two different kinds of nuclei. A diploid germinal micronucleus transmits the genetic information to the next sexual generation, while a polyploid somatic macronucleus is responsible for gene expression. Reproducible DNA elimination, which occurs in many animal lineages, takes place in ciliates during sexual reproduction, when a new somatic macronucleus develops from a copy of the germline micronucleus. The somatic genomes of numerous Paramecium species are being sequenced and annotated. ParameciumDB integrates the genomes as they become available, to provide resources for functional and comparative genomics to the community. ParameciumDB interfaces and tools have been redesigned. Your feedback is welcome.草履虫（Paramecium）是一类隶属于纤毛门（ciliate phylum）的大型单细胞真核生物，其中双小核草履虫（P. aurelia，Paramecium aurelia）的个体尺寸约为120微米。纤毛虫与最后真核共同祖先（Last Eukaryotic Common Ancestor）类似，拥有以振动纤毛形式存在的轴丝结构（axonemal structure），该结构可介导运动与摄食，同时在接合生殖（conjugation，即有性生殖）过程中，对不同交配型草履虫的配对行为至关重要。与多细胞真核生物类似，纤毛虫分化出生殖与体部功能，拥有两种不同的细胞核：二倍体生殖微核（germinal micronucleus）负责将遗传信息传递给下一代有性个体，而多倍体体部大核（somatic macronucleus）则承担基因表达的功能。可重复的DNA消除现象广泛存在于多个动物类群中，在纤毛虫的有性生殖过程中同样会发生，此时新的体部大核由生殖微核的拷贝发育而来。目前已有多种草履虫的体部基因组正在被测序与注释。草履虫数据库（ParameciumDB）会收录所有公开可用的基因组数据，为科研共同体提供功能基因组学与比较基因组学相关的研究资源。草履虫数据库的界面与工具已完成重新设计。欢迎广大用户提出宝贵反馈意见。

搜集汇总

背景与挑战

背景概述

ParameciumDB是一个整合多种草履虫物种基因组数据的数据库，旨在为功能与比较基因组学研究提供资源。该数据库已重新设计其界面和工具，以更好地服务科研社区。