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Development of peptidomimetic inhibitors of the ERG transcription factor in prostate cancer (expression)

ChEBI2014-07-15 更新2026-07-21 收录

前列腺癌靶向治疗

肽模拟药物开发

数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-58940 数据链接链接失效反馈

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资源简介：

Development of peptidomimetic inhibitors of the ERG transcription factor in prostate cancer (expression)

应用场景：

创建时间：

2014-07-15

前列腺癌靶向治疗

放射性药物研发

Prostate-specific membrane antigen (PSMA) is a promising target for the diagnosis and radionuclide therapy of prostate cancer. This study reports conversion of a previously reported 68Ga-imaging agent

NIAID Data Ecosystem110

Physachenolide C is a Potent, Selective BET Inhibitor

BET抑制剂

前列腺癌靶向治疗

A pulldown using a biotinylated natural product of interest in the 17β-hydroxywithanolide (17-BHW) class, physachenolide C (PCC), identified the bromodomain and extra-terminal domain (BET) family of p

Figshare2022-12-28 更新80

Therapeutic targeting MDR1 expression by RORγ antagonists resensitizes cross-resistant CRPC to taxane via coordinated induction of cell death programs

化疗耐药性

前列腺癌靶向治疗

We report here that RORγ, a nuclear receptor family member, unexpectedly mediates MDR1/ABCB1 overexpression. RORγ plays an important role in controlling the functions of subsets of immune cells and ha

NIAID Data Ecosystem40

Virtual Screening of PRK1 Inhibitors: Ensemble Docking, Rescoring Using Binding Free Energy Calculation and QSAR Model Development

药物虚拟筛选

前列腺癌靶向治疗

Protein kinase C Related Kinase 1 (PRK1) has been shown to be involved in the regulation of androgen receptor signaling and has been identified as a novel potential drug target for prostate cancer the

NIAID Data Ecosystem80

Treatment with the WNT5A-mimicking Peptide Foxy-5 Effectively Reduces the Metastatic Spread of WNT5A-low Prostate Cancer Cells in an Orthotopic Mouse Model

前列腺癌靶向治疗

癌症转移抑制模型

The raw data behind the figures of the published paper

Figshare2017-08-28 更新40