Genetic testing limits the spread of inherited kidney disease while avoiding inbreeding in domestic cats

More than 56,000 genetic variants were evaluated in 81 domestic cats to clarify the genetic structure, genetic diversity, and effective population size at two time points: before genetic testing started (2019) and after genetic testing became popular (2022)., Scottish Folds and Persian cats were genotyped by using Infinium iSelect 63K Cat DNA Array (Illumina Inc.). , , # Genetic testing limits the spread of inherited kidney disease while avoiding inbreeding in domestic cats

[https://doi.org/10.5061/dryad.6hdr7sr82](https://doi.org/10.5061/dryad.6hdr7sr82)

The data format is a Plink bed, so you can use PLINK software ([https://www.cog-genomics.org/plink/](https://www.cog-genomics.org/plink/)) to handle the data easily.

Quality control was performed using PLINK version 1.90 (Chang et al., 2015). Missing rates for each locus (geno option) and individual cats (mind option) were both <5%. We did not examine the Hardy-Weinberg equilibrium, as we did not assume random mating for pedigreed cats. Population genetic analyses should not include close relatives (Manichaikul et al., 2010); therefore, we conducted robust relationship-based pruning using the king-cutoff option in PLINK version 2.00a2LM (threshold of 0.176) to exclude pairings between monozygotic twins and first-degree relatives. For allele frequency-based quality control, we excluded SNPs with a ...,