EpiPPI Exact-Reproduction Data for Condition-Specific Direction Inference in Saccharomyces cerevisiae Protein–Protein Interaction Networks

This dataset provides the frozen processed inputs and saved stochastic run objects required to reproduce the principal results of EpiPPI, a computational framework for condition-specific direction inference in Saccharomyces cerevisiae protein–protein interaction networks. The package contains the processed yeast physical-interaction network, NCBI Gene identifier mapping, precomputed path-orientation mapping, 50 saved epiGA run objects covering five biological conditions, and reference result tables used for automated output comparison. The five evaluated conditions are heat shock, ER stress, temperature steady state, osmotic stress, and DNA damage, with ten saved epiGA runs provided for each condition. The processed PPI network was derived from BioGRID release 5.0.253. Expression information used in the broader workflow was derived from NCBI GEO accessions GSE18, GSE312455, and GSE5301. This archive supports exact reproduction of the reported network reconstruction, pathway analysis, and validation outputs. The companion GitHub repository will provide the executable code, environment specification, checksum verification, and one-command reproduction workflow. The archive includes a detailed file manifest, SHA-256 checksums, data provenance documentation, and third-party rights notices.