Synthesis of 6‑Substituted 6<i>H</i>‑Indolo[2,3‑<i>b</i>]quinolines from Isoindigos
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A facile approach to 6-aryl/alkyl substituted 6H-indolo[2,3-b]quinolines from mono-N-substituted isoindigo derivatives in the presence of SnCl2·2H2O in acid media is described. Pyrrole and pyridine rings are synchronously constructed in one pot for these tetracyclic molecules. A plausible reduction/hydrolysis/decarboxylation/cyclization/aromatization domino reaction mechanism is proposed. Bis-N-substituted isoindigo only gives the corresponding reduction product, 3,3′-bioxindole.
创建时间：
2016-12-13
