Projected effectiveness of dapagliflozin in heart failure with reduced ejection fraction in clinical practice supplementary table

Aim: To estimate the projected effectiveness of dapagliflozin in subjects with heart failure (HF) with
reduced ejection fraction in clinical practice in Spain. Materials & methods: This multicenter cohort
study included subjects aged 50 years or older consecutively hospitalized for HF in internal medicine
departments in Spain. The projected clinical benefits of dapagliflozin were estimated based on results
from the DAPA-HF trial. Results: A total of 1595 patients were enrolled, of whom 1199 (75.2%) were
eligible for dapagliflozin. Within 1 year after discharge, 21.6% of patients eligible for dapagliflozin
were rehospitalized for HF and 20.5% died. Full implementation of dapagliflozin led to an absolute risk
reduction of 3.5% for mortality (number needed to treat = 28) and 6.5% (number needed to treat = 15)
for HF readmission. Conclusion: Treatment with dapagliflozin in clinical practice may markedly reduce
mortality and readmissions for HF.