Crystal structure of a ternary complex of E. coli thymidylate synthase D169C with dUMP and the antifolate CB3717

Crystal structure of a ternary complex of E. coli thymidylate synthase D169C with dUMP and the antifolate CB3717 Descriptor: 10-PROPARGYL-5,8-DIDEAZAFOLIC ACID, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, Thymidylate synthase Authors: Birdsall, D.L, Finer-Moore, J, Stroud, R.M. Deposit date: 2002-12-05 Release date: 2002-12-25 Last modified: 2024-11-20 Method: X-RAY DIFFRACTION (2.4 Å) Cite: The only active mutant of thymidylate synthase D169, a residue far from the site of methyl transfer, demonstrates the exquisite nature of enzyme specificity. Protein Eng., 16, 2003