Aberrant expression of homeobox transcription factor HOXA9 is a central component of the leukemogenic program driven by diverse oncogenes. Here we show that HOXA9 overexpression in myeloid progenitor

干细胞与再生医学数据中心2022-02-20 更新110

Additional file 5 of Single cell characterization of B-lymphoid differentiation and leukemic cell states during chemotherapy in ETV6-RUNX1-positive pediatric leukemia identifies drug-targetable transcription factor activities

白血病研究

转录因子分析

Additional file 5: Table S4. Supporting information related to SCENIC analysis. Summary of regulons discovered in healthy BM B-lineage analysis (related to Fig. 2) and the related validation motif ana

DataCite Commons2020-11-21 更新40

白血病小鼠与正常小鼠Lepr-Tdtomato细胞 10X Genomics测序数据

白血病研究

单细胞转录组学

Lepr-Tdtomato小鼠做为受体小鼠，经尾静脉移植AML 细胞，监测外周血至发病晚期，胶原酶消化AML 与CTRL 小鼠的后肢骨，分选Tdtomato 阳性细胞，分选得到的AML小鼠与正常小鼠Lepr-Tdtomato细胞交予诺禾致源公司，进行10X Genomics单细胞转录组的建库和测序，以得到这群细胞的异质性及其在白血病下细胞亚群变化的转录数据。

国家人口健康科学数据中心130

5 pairs of Childhood B-ALL twins WGS. Homo sapiens

基因组测序

白血病研究

Whole genome sequencing of five pairs of Childhood Pre-B Cell Acute Lymphoblastic Leukemia,for identifing the Whole-genomic variations.

NIAID Data Ecosystem100