PPI prediction from sequence, gold standard dataset

Gold Standard Dataset for sequence-based PPI prediction: Big dataset (140,000 training points (Intra-0), 79,000 validation (Intra-1), 49,000 test (Intra-2)) No direct data leakage: proteins from training are not contained in validation or test, proteins from validation are not in training or test, proteins from test are not in validation or training Minimized sequence similarity between training, validation, test because whole human proteome was split with KaHIP such that sequence similarities are minimized Redundancy-reduction with CD-HIT: inside of the datasets, no proteins with >40% pairwise sequence similarity