Multivariate Cox proportional hazards models of the stemness bipartition to predict relapse-free survival when adjusting for two prognostic variables (A) residual disease and stage, (B) grade and stage or (C) grade and residual disease.

*p**p***p1In regression analyses, the ordinal variables stage and grade were broken into multiple components using default functions in R. However, only the linear components (levels treated as a continuous variable) are displayed in the table because the other components were not significant. Grade was also coded as a quadratic component (grade 2 vs. grades 1 and 3) and stage as both quadratic (stages 2 and 3 vs. stages 1 and 4) and cubic (stage 2> stage 4> stage 1> stage 3) components.