Bruton's tyrosine kinase in complex with compound PTI55

Bruton's tyrosine kinase in complex with compound PTI55 Descriptor: 4-{4-amino-1-[(3R)-1-(cyclopropanecarbonyl)piperidin-3-yl]-1H-pyrazolo[3,4-d]pyrimidin-3-yl}-N-[4-(trifluoromethoxy)pyridin-2-yl]benzamide, Tyrosine-protein kinase BTK Authors: Lin, D.Y, Andreotti, A.H, Tonge, P.J, Bravo, E, Li, X. Deposit date: 2024-11-28 Release date: 2025-08-13 Last modified: 2025-08-20 Method: X-RAY DIFFRACTION (2.03 Å) Cite: Modulating the Binding Kinetics of Bruton's Tyrosine Kinase Inhibitors through Transition-State Effects. J.Am.Chem.Soc., 147, 2025