MicroRNA expression profile of the kidney under tubulointerstitial fibrosis

In the context of renal tubulointerstitial fibrosis (TIF), aberrant changes in renal drug transporters can severely disrupt systemic drug disposition, leading to reduced therapeutic efficacy or increased toxicity. While we have previously documented alterations in drug transporters in TIF, the underlying epigenetic mechanisms remain unclear. This study aims to characterize the miRNA expression profile in TIF, elucidate the epigenetic network governing transporter dysregulation, and provide mechanistic insights to support safer drug use in CKD.