Kinetic chromatin openin profiles in mouse ApcDHep or wt hepatocytes

We analyzed chromatin opening in hepatocytes isolated from Apclox/loxlivers, after injection of adenovirus Ad5 -Cre-GFP and sorting on the basis of GFP signal at day 6, 15 and 21 post-injection. Our aims was to study the impact of an aberrant beta-catenin activation on chromatin opening in hepatocytes during the early steps of liver tumorigenesis. Overall design: ATAC-seq profiles from GFP+ ApcDHep hepatocytes isolated from ApcDHep livers versus GFP- Apcwt hepatocytes