miR-600 acts as a bimodal switcher that regulates breast cancer stem cell fate through WNT signaling

ChEBI2020-08-25 更新2026-07-12 收录

乳腺癌干细胞调控

WNT信号通路研究

数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-MTAB-5393 数据链接链接失效反馈

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miR-600 acts as a bimodal switcher that regulates breast cancer stem cell fate through WNT signaling

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2020-08-25

Control of breast cancer growth and initiation by the stem cell-associated transcription factor TCF3

乳腺癌干细胞调控

肿瘤起始机制

Regulatory factors controlling stem cell identity and self-renewal are often active in aggressive cancers and are thought to promote their growth and progression. TCF3 (also known as TCF7L1) is a memb

NIAID Data Ecosystem60

Long non coding RNA (lncRNA) SCIRT regulates mitotic and stemness genes in breast cancer stem cells. Long non coding RNA (lncRNA) SCIRT regulates mitotic and stemness genes in breast cancer stem cells

乳腺癌干细胞调控

lncRNA靶基因识别

CHART sequencing has been carried out in order to evaluate SCIRT target genes in MDA-MB-231 sphere derived cells. We discovered that lncRNA SCIRT binds promoter region of genes whose expression change

NIAID Data Ecosystem40

ER-α36-Mediated Rapid Estrogen Signaling Positively Regulates ER-Positive Breast Cancer Stem/Progenitor Cells

乳腺癌干细胞调控

激素信号通路

The breast cancer stem cells (BCSC) play important roles in breast cancer occurrence, recurrence and metastasis. However, the role of estrogen signaling, a signaling pathway important in development a

Figshare2016-01-18 更新20

Elucidating and Pharmacologically Targeting Master Regulators of Stem-like Breast Cancer Cell State (CROP-Seq)

乳腺癌干细胞调控

单细胞CRISPR筛选

In many tumors, small subpopulations of stem-like cells can exist in drug-resistant states that are transient and epigenetically governed. Single-cell RNA sequencing (scRNA-seq) provides transcription

NIAID Data Ecosystem60

Identification_of_BCL11A_targets_by_CHIP_Seq. Identification_of_BCL11A_targets_by_CHIP_Seq

乳腺癌干细胞调控

转录因子靶点

We have recently identified BCL11A as a key regulator of mammary stem (MaSC) and progenitor cells. Deletion of BCL11A in MaSC leads to loss of ability of those cells to engraft a cleared mammary fatpa

NIAID Data Ecosystem30

miR-600 acts as a bimodal switcher that regulates breast cancer stem cell fate through WNT signaling

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