SNP distribution Elite controllers vs controls

<b>SNP distribution Elite controllers vs controls</b><br>In this study, we compared 543 European Elite Controllers from the International Collaboration on HIV-1 Genomics (ICGH) to and 3,272 controls individuals. This involved a meta-analysis of two case-control comparisons, leading to the identification of 2,626 significant SNPs (p&lt;5.10-8) within the Major Histocompatibility Complex (MHC) region and revealed an extensive haploblock spanning 1.9 megabases in the MHC region, comprising 379 SNPs and tagging HLA-B*57:01.The Table herewith presents the distribution of the significant SNPs in the Elite controllers and Control populations and their corresponding p-values. The SNPs forming the haploblock linked to HLA-B*57:01 allele are marked by a "yes" in the column « haploblock ».For more information contact the coordinators of the project :<br>Paul Mclaren: [e-mail]<br>Jean-François Zagury: [e-mail]<br><br><b>Description of the data and file structure</b><br>Genotypic data was generated using three genotyping arrays: Illumina 550, Illumina 650, and Illumina 1M. Prior to analysis, we conducted standard quality control (QC) procedures to ensure the use of clean data. We then could impute an analyse 35,552 SNPs in the MHC region.