Difluoro-Substituted Bicyclo[1.1.1]pentanes for Medicinal Chemistry: Design, Synthesis, and Characterization
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下载链接：
https://figshare.com/articles/dataset/Difluoro-Substituted_Bicyclo_1_1_1_pentanes_for_Medicinal_Chemistry_Design_Synthesis_and_Characterization/9941852
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资源简介：
A practical synthetic
approach to the difluoro-substituted bicyclo[1.1.1]pentanes
was developed. The key step was an addition of difluorocarbene (:CF2) to electron-rich bicyclo[1.1.0]butanes by the CF3TMS/NaI system. The obtained difluoro-bicyclo[1.1.1]pentanes are
suggested to be used as saturated bioisosteres of benzene rings for
the purpose of drug discovery projects.
创建时间：
2019-09-25
