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Loss of Cardiac microRNA-Mediated Regulation Leads to Dilated Cardiomyopathy and Heart Failure.

ChEBI2011-10-11 更新2026-07-21 收录

心脏microRNA调控

扩张型心肌病机制

数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-32881 数据链接链接失效反馈

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资源简介：

Loss of Cardiac microRNA-Mediated Regulation Leads to Dilated Cardiomyopathy and Heart Failure.

应用场景：

创建时间：

2011-10-11

扩张型心肌病机制

疾病建模

Purpose: LMNA-DCM accounts for 5-10% of DCM cases and has an age-related penetrance whose onset typically appears between the ages of 30 and 40. However, the precise mechanisms linking the LMNA mutati

NIAID Data Ecosystem80

Natural genetic variation of the cardiac transcriptome in non-diseased donors and patients with dilated cardiomyopathy

器官转录组学

扩张型心肌病机制

Background: Genetic variation is an important determinant of RNA transcription and splicing, which in turn contributes to variation in human traits including cardiovascular diseases.Results: Here we r

NIAID Data Ecosystem60

Deletion of the RS domain in RBM20 leads to dilated cardiomyopathy

扩张型心肌病机制

基因功能缺失致病性研究

Human patients carrying genetic mutations in RBM20 develop a clinically aggressive dilated cardiomyopathy (DCM) characterized by early onset heart failure, high mortality, and sudden death, which is r

NIAID Data Ecosystem40

RNA-seq of Mtfp1 KO and WT mice at the pre-symptomatic stage and at the onset of dilated cardiomyopathy. RNA-seq of Mtfp1 KO and WT mice at the pre-symptomatic stage and at the onset of dilated cardiomyopathy

基因功能研究

扩张型心肌病机制

Transcriptomic analysis was performed to gain further insights into the molecular and cellular mechanisms underlying cardiac pathology.

NIAID Data Ecosystem70

importance of MTFP1 partners for mitochondrial function in the heart

线粒体功能障碍

扩张型心肌病机制

Mitochondria are paramount to the metabolism and survival of cardiomyocytes. Here we show that Mitochondrial Fission Process 1 (MTFP1) is essential for cardiac structure and function. Constitutive k

NIAID Data Ecosystem50

Loss of Cardiac microRNA-Mediated Regulation Leads to Dilated Cardiomyopathy and Heart Failure.

资源简介：

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