Cysteine mutations in αIIbβ3 designed to limit or stabilize conformational changes.
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These cross-links were designed to limit: both extension and swing-out (αIIbR320C/β3R563C) [9], swing-out (β3T329C/A347C [14] and αIIb319/β3V359C [17]), αIIb extension (R597C-Y645C) [16], or β3 extension (S367C/S551C, G382C/T564C, and V332C/S674C) [17]. A β3 V332C/M335C disulfide mutant was designed to induce swing-out.
创建时间：
2015-12-02
