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Blimp-1 moulds the epigenetic architecture of IL-21-mediated autoimmune diseases through an autoregulatory circuit

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NIAID Data Ecosystem2026-03-14 收录
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https://www.ncbi.nlm.nih.gov/sra/SRP369079
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To unravel how Blimp-1 systematically manipulates the global transcriptional landscape in CD4 T cells to contribute to autoimmune progression, we performed RNA sequencing analysis in Blimp-1 transgenic (BTg) or Blimp1-deficient (CKO) NOD mice Overall design: Sorted total CD4 T cells from spleens of 12-week-old control, CKO and BTg NOD mice, without further T cell receptor stimulation
创建时间:
2022-12-31
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