Marginal effects of FXa on key regulators of the nitric oxide-cGMP pathway in endothelial cells.
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Incubation of HUVECs with FXa for 6 hours reduces eNOS (A) and increases PDE5 (D) mRNA expression significantly only at the highest concentration of 30 nM. No effect on sGC alpha 1 (B) and sGC beta 1 (C) is detectable. Data shown as mean ± SEM (n = 6/group). *p<0.05, ***p<0.001 vs cells not exposed to thrombin.
创建时间：
2016-02-29
