Differential gene expression in IDH1-R132H Tumor Neurospheres generated from a mouse model of Low Grade Glioma
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE94974
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资源简介：
IDH1-R132H is expressed in Low Grade Glioma (LGG) in combination with mutation in ATRX and TP53 genes. IDH1-R132H results in gain of function with production of 2-hydroxygluatrate, that in turn generates a hypermethylatyed phenotype in DNA and histone with consequences in epigenetic regulation of gene expression. Here we will compare the gene expression profile between IDH1-R132H and IDH1 Wt tumor neurospheres. Evaluate differential gene expression between tumor neurospheres IDH1-R132H and IDH1 wt.
创建时间：
2019-05-15
