Mortality of encephalitis hospitalizations, 2000–2010.

Abbreviations: SE = standard error; OR = Odds Ratio; CI = Confidence Interval; HIV/AIDS = Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome; HSV = Herpes Simplex Virus; VZV = Varicella Zoster Virus; HHV = Human Herpesvirus; NOS = not otherwise specified.NA = not available due to observations ≤10 admissions suppressed in compliance with Agency for Healthcare Research and Quality guidelines.a) 392 admissions (n = 2,364 weighted) with missing death, sex, or hospital location/teaching status were excluded.b) Total deaths were weighted to represent the entire US population using discharge weights provided by the Nationwide Inpatient Sample.c) The logistic regression model excludes the following disease categories: Unspecified, Other viral, Other infectious, Viral NOS, and Toxoplasmosis (n = 26,232; 128,679 weighted); Final unweighted n = 21,972, weighted n = 107,985. Model constant = 0.012 ± 0.003; Model calibration: Hosmer and Lemeshow goodness-of-fit test: χ2 = 1.803, df = 9, P = 0.063.d) The Charlson Comorbidity Index is a weighted index based on the presence of 17 comorbid conditions. Each comorbid disease is assigned a weight from 1 to 6; the index is the sum of the weights for each comorbid condition and can range from 0 to 33. For the purposes of this study, mild was score = 0, moderate score = 1, and severe score ≥ 2.e) Cancer deaths include both metastatic (30%) and nonmetastatic (70%); crude mortality rates are 15.1% and 14.5%, respectively.Mortality of encephalitis hospitalizations, 2000–2010.