Chiral Cyclopentadienyl Cobalt(III) Complexes Enable Highly Enantioselective 3d-Metal-Catalyzed C–H Functionalizations
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https://figshare.com/articles/dataset/Chiral_Cyclopentadienyl_Cobalt_III_Complexes_Enable_Highly_Enantioselective_3d-Metal-Catalyzed_C_H_Functionalizations/7903667
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资源简介：
The
synthesis of a set of cobalt(III)-complexes equipped with trisubstituted
chiral cyclopentadienyl ligands is reported, and their steric and
electronic parameters are mapped. The application potential of these
complexes for asymmetric C–H functionalizations with 3d-metals
is shown by the synthesis of dihydroisoquinolones from N-chlorobenzamides with a broad range of alkenes. The transformation
proceeds with excellent enantioselectivities of up to 99.5:0.5 er and high regioselectivities. The observed values outperform
the best rhodium(III)-based methods for this reaction type. Moreover,
challenging substrates such as alkyl alkenes also react with high
regio- and enantioselectivities.
创建时间：
2019-03-27
