DNA methylation at the 5-position of cytosine (5mC) is a crucial epigenetic mark in regulating biological processes including gene silencing, gene imprinting, and X chromosome inactivation. It has lon

NIAID Data Ecosystem00

Stage-specific Kdm6b-transcription factor partnerships orchestrate temporal precision during stepwise motor neuron differentiation [RNA-seq]

运动神经元

表观遗传调控

Histone modifiers instruct cellular differentiation, yet how they achieve temporal precision remains enigmatic. Here we demonstrate that the H3K27 demethylase Kdm6b acts as a master epigenetic conduct

NIAID Data Ecosystem00

DNA dioxygenases Tet2/3 control epithelial differentiation [RNA-seq]

毛囊上皮分化

表观遗传调控

Execution of lineage-specific differentiation programs requires tight coordination between many regulators including Ten-eleven translocation (TET) family enzymes catalyzing 5-methylcytosine oxidation

Alliance of Genome Resources00

An epigenetic switch in vascular phenotype augments anti-tumor immunity [bulkRNA-seq]

肿瘤免疫微环境

表观遗传调控

The abnormal tumor vasculature can present a barrier to the infiltration of anti-tumor immune cells, which impairs immune surveillance and response to immunotherapy. Here, we show that targeting the e

NIAID Data Ecosystem00

E-GEOD-116066

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