Tran2009_CaDynamicsSERCA_Cardiac

This a model from the article:
A thermodynamic model of the cardiac sarcoplasmic/endoplasmic Ca(2+) (SERCA)
pump.

Tran K, Smith NP, Loiselle DS, Crampin EJ. Biophys J
2009 Mar 4;96(5):2029-42 19254563
,
Abstract:

We present a biophysically based kinetic model of the cardiac SERCA pump that
consolidates a range of experimental data into a consistent and
thermodynamically constrained framework. The SERCA model consists of a number of
sub-states with partial reactions that are sensitive to Ca(2+) and pH, and to
the metabolites MgATP, MgADP, and Pi. Optimization of model parameters to fit
experimental data favors a fully cooperative Ca(2+)-binding mechanism and
predicts a Ca(2+)/H(+) counter-transport stoichiometry of 2. Moreover, the order
of binding of the partial reactions, particularly the binding of MgATP, proves
to be a strong determinant of the ability of the model to fit the data. A
thermodynamic investigation of the model indicates that the binding of MgATP has
a large inhibitory effect on the maximal reverse rate of the pump. The model is
suitable for integrating into whole-cell models of cardiac electrophysiology and
Ca(2+) dynamics to simulate the effects on the cell of compromised metabolism
arising in ischemia and hypoxia.
This model was taken from the CellML repository
and automatically converted to SBML.
The original model was:
Tran K, Smith NP, Loiselle DS, Crampin EJ. (2009) - version=1.0

The original CellML model was created by:
Kenneth Tran

[e-mail]
The University of Auckland
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