Table S1: Sex Differences in echocardiographic parameters

Serially measured echocardiographic parameters for three, (W3), six (W6), and ten (W10) week old WT and MLP-/- mice reported as mean ± SEM (N). The following markers denote statistically significant (p < 0.05) differences between these comparisons: ‘*’ WT group of the same age, ‘#’ the marked group and the corresponding W3 time point, ‘†’ the marked group and the corresponding W6 time point, ‘$’ the marked post-dobutamine parameter and the corresponding pre-dobutamine parameter of the same group. Pre-post dobutamine comparisons were only made between paired samples. ‘&’ denotes that comparisons between time points were not made due to attrition. Abbreviations: BW: body weight, ESV: end systolic volume, EDV: end diastolic volume, SV: stroke volume, HR: heart rate, ESD: end systolic diameter, EDD: end diastolic diameter, LV: left ventricular, PWTd: posterior wall thickness at diastole, EF: ejection fraction, FS: fractional shortening, DOB: dobutamine, Δ: difference between dobutamine and baseline values, PR: time between P and R waves, MVET: mitral valve ejection time, IVCT: isovolumic contraction time, IVRT: isovolumic relaxation time, AET: aortic ejection time, e’: peak mitral annulus velocity during early filling, a’: peak mitral annulus velocity during late filing, E: peak transmitral blood velocity during early filling, A: peak transmitral blood velocity during late filing, L: distance between apical and basal short axis images, GLS: global longitudinal strain, Pk; peak value, T2P; time to peak, SRS; systolic radial strain, SRSR; systolic radial strain rate, DRSR; diastolic radial strain rate.