Monocytes transition to monocyte-macrophages within the inflamed vasculature via CCR2 on monocytes and endothelial TNFR2
收藏NIAID Data Ecosystem2026-03-13 收录
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Our study reports that CCR2 dependent functional specialization of monocytes into immature macrophages occurs within the TNF-TNFR2 activated vasculature and establishes a chemokine-based autocrine, feed-forward loop that may aplify the inflammation and renal injury. Overall design: Nephrotoxic Nephritis induced in 10, eight week old WT mice. Different populations of monocytes were FACS sorted and cells were processed for bulk RNAseq
创建时间：
2022-02-21
