Mistranslation accelerates the adaptation of Candida albicans to Fluconazole
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https://www.ncbi.nlm.nih.gov/sra/ERP009465
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资源简介：
The leucine CUG codon was reassigned to serine in the fungal pathogen Candida albicans. To clarify the biological role of this tuneable codon ambiguity on drug resistance, we evolved C. albicans strains that were engineered to mistranslate the CUG codon at constitutively elevated levels, in the presence and absence of the antifungal drug fluconazole. Elevated levels of mistranslation resulted in the rapid acquisition of resistance to fluconazole.
创建时间：
2023-10-13
