Expression data from epithelial cells of nasal mucosa

As the first defense line to contact respiratory allergens, epithelial cells play an extremely critical role in the occurrence of allergic rhinitis, and the mechanism is realized by the regulation of the expression of co-expressed mRNA which is controlled by lncRNA. We used microarrays to screen gene expression profiles in nasal mucosal epithelial cells of allergic rhinitis, and predicted the relationship between lncRNA and mRNA by bioinformatics analysis. Patients who need the operation of nasal septal correction were selected, part of the inferior turbinate mucosa was taken as experimental samples during the operation. According to the diagnosis guidelines of allergic rhinitis, the samples were divided into AR group and non-AR group, and 3 samples were selected for microarray analysis in each group.Then we analyzed the function of differentially expressed genes.