Transforming Growth Factor-β (TGFβ) Prevents Hypertension-Induced Aortic Dissection in Adult Mice via Extracellular Matrix Production (Single cells KO vs. WT SMC)

We report single-cell RNA-seq data of Myh11 lineage marked smooth muscle cells (SMCs) from murine aortas at 1 week after conditional disruption of TGFβ signaling versus controls Ascending aorta/aortic arch segments were procured from tamoxifen-treated, 12-week-old Myh11-CreERT2.mT/mG (designated as GFPiSMC or simply WT) or Tgfbr1f/f.Tgfbr2f/f.Myh11-CreERT2.mT/mG (designated as Tgfbr1/2iSMCKO or simply KO) mice, GFP+ SMCs were isolated after cryophilic enzyme digestion, and single-cell RNA-seq analysis was performed