Diaphragm EMG and plethysmography metrics from male Sprague-Dawley wildtype rats and rats with Pompe disease

STUDY PURPOSE: Pompe disease is a genetic disorder caused by acid a-glucosidase mutations, leading to an accumulation of glycogen including within motor neurons and ultimately causing cardiorespiratory failure. Here, we sought to establish a 'respiratory signature' of disease across the lifespan in a rodent model of Pompe disease. DATA COLLECTED: The data collected here is from 6 wildtype and 6 Pompe male rats. Concurrent recordings of diaphragm EMG and plethysmography were made once a month from 4 to 10 months of age, and included exposures to baseline normoxic air (21% O2, 79% N2), hypercapnia (21% O2, 7% CO2, balanced N2), hypoxia (10.5% O2, balanced N2), and hypercapnic-hypoxia (10.5% O2, 7% CO2 balanced N2). This dataset includes respiratory frequency, EMG to inspiration latency, expiratory/inspiratory plethysmography peak ratio, and metrics of sniffing/exploratory behavior. DATA USAGE NOTES: