Raw Lipidomics Dataset for: "Perturbation of de novo lipogenesis hinders MERS-CoV assembly and release, but not the biogenesis of viral replication organelles"

The dataset contains the raw values as obtained from a targeted lipidomics analysis, which was part of the study "Perturbation of de novo lipogenesis hinders MERS-CoV assembly and release, but not the biogenesis of viral replication organelles".

The experimental aim was the analysis of lipidome changes on lipid class level. The values represent the relative abundance of each lipid class compared to the total lipidome. For this study, Huh7 cells were treated with a small molecule inhibitor (TOFA) and lipidome changes were compared to the levels of DMSO-treated control cells. The file contains the raw values of the TOFA-treated Huh7 cells, DMSO-treated cells, untreated Huh7 cells and standards used (blanks, quality control cells and quality control plasma). Our findings suggested a metabolic switch towards lipolysis due to the compound's mechanism of action.

For further information over the data acquisition method please refer to the materials and methods and the Targeted Lipidomics Analysis section of the study, as posted on bioRxiv (DOI: https://doi.org/10.1101/2024.08.21.608937). A revised version of the study is currently submitted/under revision.