MiR146a-loaded engineered exosomes released from silk fibroin patch promote diabetic wound healing

Unhealable diabetic wounds need to be addressed with the help of newer, more efficacious strategies. Exosomes combined with biomaterials for sustained delivery of therapeutic agents are expected to bring new hope for chronic wound treatment. Here, the engineered exosomes modified for efficiently loading miR-146a and attaching to silk fibroin patch were demonstrated to promote diabetic wound healing. The transcriptomics analysis suggested anti-inflammatory and regenerative effects with SGM-miR146a-Exo@SFP treatment. Transcriptomics analysis GO enrichment and KEGG enrichment to the differentially expressed mRNAs of wounds treated with or without SGM-miR146a-Exo@SFP at day 3 and day 7 post-wounding.