Predictive value of apelin-12 in ST-elevation myocardial infarction patients with different renal function: a prospective observational study

Objectives: To investigate the factors predicting the onset of major adverse cardiovascular events (MACEs) after primary percutaneous coronary intervention (pPCI) for ST-segment elevation myocardial infarction (STEMI) patients.
Background: apelin-12 has been regarded acting essential role in cardiovascular homeostasis. However, current knowledge of the optimal prognostic predictive value is limited.
Methods: 464 STEMI patients (63.0±11.9 years, 355 men) who underwent successful pPCI were enrolled. Patients were followed-up for 2.5 years. Multivariate cox regression analyses and receiver operating characteristic curve analysis were performed to determine the factors predicting MACEs.
Results: There were 118 patients (25.4%) who experienced MACEs in the follow-up period. Multivariate cox regression analysis demonstrated that low apelin-12 (HR=0.132, 95% CI=0.060-0.292, p＜0.001), low left ventricular ejection fraction (LVEF) (HR=0.965, 95% CI=0.941-0.991, p=0.007), low estimated glomeru...