Chemoproteomic Cysteine Selectivity of VVD-065, VVD-330 and VVD-325

NIAID Data Ecosystem2026-05-10 收录

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KEAP1靶点验证

数据链接：

https://www.omicsdi.org/dataset/pride/PXD071657 数据链接链接失效反馈

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资源简介：

Global assessment of cysteine selectivity for VVD compounds that covalently engage KEAP1 C151

创建时间：

2025-12-10

Covalent Data Screen of TBXTA-C006

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质谱标记

Uploaded data set contains the mass spec labelling data covalent inhibitor campaign against TBXTA-C006. The data was collected at Oxford and it contains the Structure IDs we use, the SMILE strings, an

NIAID Data Ecosystem50

HOIP-fragment5 complex

蛋白质结构解析

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HOIP-fragment5 complex Descriptor: 1,2-ETHANEDIOL, E3 ubiquitin-protein ligase RNF31, SODIUM ION, ... Authors: Johansson, H, Tsai, Y.C.I, Fantom, K, Chung, C.W, Martino, L, House, D, Rittinger, K. Dep

Protein Data Bank Japan2024-10-16 更新40

Neolymphostin A Is a Covalent Phosphoinositide 3‑Kinase (PI3K)/Mammalian Target of Rapamycin (mTOR) Dual Inhibitor That Employs an Unusual Electrophilic Vinylogous Ester

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天然药物发现

Using a novel chemistry-based assay for identifying electrophilic natural products in unprocessed extracts, we identified the PI3-kinase/mTOR dual inhibitor neolymphostin A from Salinispora arenicola

NIAID Data Ecosystem30

甲状腺激素受体拮抗

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Thyroid hormone (T3) mediates diverse physiological functions including growth, differentiation, and energy homeostasis through the thyroid hormone receptors (TR). The TR binds DNA at specific recogni

NIAID Data Ecosystem40

An Anti-Cancer Gold(III)-Activated Porphyrin Scaffold that Covalently Modifies Protein Cysteine Thiols

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药物发现

Cysteine thiols of many cancer-associated proteins are attractive targets of anti-cancer agents. Herein, we unequivocally demonstrate a distinct thiol-targeting property of gold(III) mesoporphyrin IX

NIAID Data Ecosystem30

Chemoproteomic Cysteine Selectivity of VVD-065, VVD-330 and VVD-325

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