Investigation of circular RNA expression profiles in ultrasound-guided radiofrequency ablation-treated transplanted tumor models of human liver cancer. Investigation of circular RNA expression profiles in ultrasound-guided radiofrequency ablation-treated transplanted tumor models of human liver cancer

Following RFA treatment, 76 DE-circRNAs were detected (|fold changes |>1.5, P-value <0.05), among which 21 were up-regulated and 55 were down-regulated. Overall design: We established a subcutaneous tumor transplantation model in 8 immunodeficient mice (Balb/c nude mice), of which 4 mice received incomplete ultrasound-guided RFA treatment and 4 mice received no treatment and were designated as the control group. Using Agilent Scanner G2505C to analyze the circRNA expression profile and its change in the HepG2-transplanted nude mice treated with incomplete RFA .