DataSheet1_Poly(aniline-co-melamine)@MnFe2O4 nanocatalyst for the synthesis of 4,4′-(arylmethylene) bis (1H-pyrazole-5-ol) derivatives, and 1,4- dihydropyrano[2,3-c]pyrazoles and evaluation of their antioxidant, and anticancer activities.docx

In this work, magnetic poly(aniline-co-melamine) nanocomposite as an efficient heterogeneous polymer-based nanocatalyst was fabricated in two steps. First, poly(aniline-co-melamine) was synthesized through the chemical oxidation by ammonium persulfate, then the magnetic nanocatalyst was successfully prepared from the in-situ coprecipitation method in the presence of poly(aniline-co-melamine). The resulting poly(aniline-co-melamine)@MnFe2O4 was characterized by FTIR, FESEM, XRD, VSM, EDX, TGA, and UV-vis analyses. The catalytic activity of poly(aniline-co-melamine)@MnFe2O4 was investigated in the synthesis of 4,4′-(arylmethylene)bis(1H-pyrazole-5-ol) derivatives, and new alkylene bridging bis 4,4′-(arylmethylene)bis(1H-pyrazole-5-ol) derivatives in excellent yields. The yield of 1,4-dihydropyrano[2,3-c]pyrazoles, 4,4′-(arylmethylene)bis(1H-pyrazol-5-ol), yields, and new alkylene bridging bis 4,4′-(arylmethylene)bis(1H-pyrazol-5-ol) derivatives were obtained 89%–96%, 90%–96%, and 92%–96%, respectively. The poly(aniline-co-melamine)@MnFe2O4 nanocatalyst can be recycled without pre-activation and reloaded up to five consecutive runs without a significant decrease in its efficiency. In addition, the antioxidant activity of some derivatives was evaluated by DPPH assay. Results showed that the maximum antioxidant activity of 4,4′-(arylmethylene)bis(1H-pyrazole-5-ol) derivatives and 1,4-dihydropyrano[2,3-c]pyrazoles were 75% and 90%, respectively. Furthermore, 4,4′-(arylmethylene)bis(1H-pyrazole-5-ol) derivatives and 1,4-dihydropyrano[2,3-c]pyrazoles showed good potential for destroying colon cancer cell lines. Consequently, the poly(aniline-co-melamine)@MnFe2O4 nanocomposite is an excellent catalyst for green chemical processes owing to its high catalytic activity, stability, and reusability.

本研究中，通过两步法成功制备了一种高效的异相聚合物基纳米催化剂——磁性聚（苯胺-共-三聚氰胺）纳米复合材料。首先，通过过硫酸铵的化学氧化作用合成了聚（苯胺-共-三聚氰胺），随后在聚（苯胺-共-三聚氰胺）的存在下，采用原位共沉淀法成功制备了磁性纳米催化剂。所得的聚（苯胺-共-三聚氰胺）@MnFe2O4 纳米复合材料通过傅里叶变换红外光谱（FTIR）、场发射扫描电子显微镜（FESEM）、X射线衍射（XRD）、振动样品磁强计（VSM）、能谱分析（EDX）、热重分析（TGA）和紫外-可见光谱（UV-vis）进行了表征。在4,4'-（芳基亚甲基）双（1H-吡唑-5-醇）衍生物的合成中，研究了聚（苯胺-共-三聚氰胺）@MnFe2O4 的催化活性，并获得了优异的产率。1,4-二氢吡喃[2,3-c]吡唑、4,4'-（芳基亚甲基）双（1H-吡唑-5-醇）及其新型亚乙烯基桥连双4,4'-（芳基亚甲基）双（1H-吡唑-5-醇）衍生物的产率分别为89%-96%、90%-96%和92%-96%。聚（苯胺-共-三聚氰胺）@MnFe2O4 纳米催化剂在无需预活化的条件下可重复使用，并在连续五次循环使用后，其效率未出现显著下降。此外，通过DPPH法对某些衍生物的抗氧化活性进行了评估。结果显示，4,4'-（芳基亚甲基）双（1H-吡唑-5-醇）衍生物和1,4-二氢吡喃[2,3-c]吡唑的最大抗氧化活性分别为75%和90%。进一步研究表明，4,4'-（芳基亚甲基）双（1H-吡唑-5-醇）衍生物和1,4-二氢吡喃[2,3-c]吡唑在破坏结肠癌细胞系方面具有良好潜力。因此，聚（苯胺-共-三聚氰胺）@MnFe2O4 纳米复合材料因其高催化活性、稳定性和可重复使用性，成为绿色化学工艺的理想催化剂。