Transcriptome analysis unveils Gln3 role in amino acids assimilation and azole resistance in Candida glabrata.

This study was focused on the transcriptional changes of the opportunistic human pathogen Candida glabrata, during ammonium growth. In order to elucidate the role of the transcriptional factor Gln3 in the Nitrogen metabolism, we carried out a RNA-seq study of the wild-type and gln3 mutant strains. Interestingly, additional to the differential expression of some genes described for Saccharomyces cerevisiae involved in the nitrogen catabolic repression, we found a set of genes with high expression in gln3 mutant, that have been reported in the fluconazole resistenace of C. glabrata.