Crystal structure of FGFR1-Y563C (FGFR4 surrogate) covalently bound to H3B-6527

Protein Data Bank Japan2024-10-30 更新2026-03-21 收录

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Crystal structure of FGFR1-Y563C (FGFR4 surrogate) covalently bound to H3B-6527 Descriptor: 1,2-ETHANEDIOL, Fibroblast growth factor receptor 1, N-{2-[(6-{[(2,6-dichloro-3,5-dimethoxyphenyl)carbamoyl](methyl)amino}pyrimidin-4-yl)amino]-5-(4-ethylpiperazin-1-yl)phenyl}propanamide, ... Authors: Tsai, J.H.C, Reynolds, D, Fekkes, P, Smith, P, Larsen, N.A. Deposit date: 2017-04-30 Release date: 2017-05-24 Last modified: 2024-10-30 Method: X-RAY DIFFRACTION (2.2 Å) Cite: H3B-6527 Is a Potent and Selective Inhibitor of FGFR4 in FGF19-Driven Hepatocellular Carcinoma. Cancer Res., 77, 2017

创建时间：

2017-04-30