DBU-Catalyzed Alkyne–Imidate Cyclization toward 1‑Alkoxypyrazino[1,2‑a]indole Synthesis
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资源简介：
1-(Propargyl)indol-2-carbonitriles react with alcohols to afford 1-alkoxypyrazino[1,2-a]indoles under DBU-catalyzed microwave-assisted conditions. The reaction scope includes a wide range of indoles, primary and secondary alcohols, and a thiol. The initial mechanistic study shows that the domino process presumably proceeds through an alkyne–allene rearrangement, imidate formation, and nucleophilic cyclization reaction sequence.
创建时间：
2018-07-19
