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A single cell-based computational platform to identify chemical compounds targeting desired sets of transcription factors for cellular conversion

NIAID Data Ecosystem2026-03-14 收录

单细胞药物筛选

细胞重编程调控

数据链接：

https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE162910 数据链接链接失效反馈

官方服务：

资源简介：

This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

应用场景：

创建时间：

2022-11-20

视网膜退行性疾病修复机制

细胞重编程调控

Contrasting with fish or amphibian, retinal regeneration from Müller glial cells is largely limited in mammals. In our quest towards the identification of molecular cues that may boost their stemness

NIAID Data Ecosystem80

Diverse Heterochromatin-Associated Proteins Repress Distinct Classes of Genes and Repetitive Elements (RNA-seq)

异染色质蛋白功能筛选

细胞重编程调控

Heterochromatin, typically marked by H3K9me3 or H3K27me3, is key to the repression of genes and repetitive elements. The mechanisms responsible for establishing and maintaining heterochromatin in a lo

NIAID Data Ecosystem30

Myc and SAGA Rewire an Alternative Splicing Network During Early Somatic Cell Reprogramming [Reprogramming_ChIPSEQ]

细胞重编程调控

剪接网络

Myc and SAGA Rewire an Alternative Splicing Network During Early Somatic Cell Reprogramming [Reprogramming_ChIPSEQ]

ChEBI2015-04-15 更新20

Master regulators and cofactors of human neuronal cell fate specification identified by CRISPR gene activation screens [CAS_TF_sgASCL1_Screen_AmpliconSeq]

细胞重编程调控

CRISPRi筛选

Technologies to reprogram cell-type specification have revolutionized the fields of regenerative medicine and disease modeling. Currently, the selection of fate-determining factors for cell reprogramm

NIAID Data Ecosystem30

Chromatin accessibility assay in Zfp266 Wt and KO cells, in mouse embryonic fibroblasts and at 72 hours of OSKM reprogramming. Chromatin accessibility assay in Zfp266 Wt and KO cells, in mouse embryonic fibroblasts and at 72 hours of OSKM reprogramming

染色质可及性分析

细胞重编程调控

We used Omnni-ATAC-Sequencing to generate chromatin accessibility maps of the genome in Zfp266 KO and Wt control cells, both in mouse embryonic fibroblasts (MEFs) and at an early stage of reprogrammin

NIAID Data Ecosystem20

A single cell-based computational platform to identify chemical compounds targeting desired sets of transcription factors for cellular conversion

资源简介：

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