Integrating transcriptomics and metabolomics to analyze the mechanism of hypertension-induced hippocampal injury

Hypertension-induced damage to the hippocampus not only leads to behavioral changes, but also to various brain diseases, but the mechanisms underlying hippocampal lesions are still unclear. The 32-week-old spontaneously hypertensive rats (SHR) and Wistar-Kyoto (WKY) rats were selected as the study subjects. The behavioral characteristics of rats were evaluated by behavioral experiments and comprehensive transcriptomic and metabolomic analysis was performed. Comprehensive analysis showed that hypertension-induced hippocampal lesions are closely associated with the metabolites and genes.