Model of JFH1-Derived p7

This model was constructed by using the secondary structure of a GT 1b p7 variant recently solved by nuclear magnetic resonance as a template (F. Penin et al., unpublished data) and Swiss Model server facilities (http://www.expasy.ch/swissmod/). The structure backbone is represented as ribbon and only the side chains of amino acids mutated in this study and of the residues likely involved in inter-helix interactions are shown. Color code is as follows: Ser, Thr, Asn, and Glu (yellow); Cys (green); His (cyan); Arg and Lys (blue); Glu (red); Trp (magenta); Tyr (purple); any other hydrophobic residue (gray). This figure was generated with Rasmol 2.7 program. The phospholipid bilayer is schematically represented. (74 KB PDF)