Total Synthesis of Clavilactone B: A Radical Cyclization–Fragmentation Strategy
收藏NIAID Data Ecosystem2026-03-06 收录
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A new synthetic route to clavilactone B, a naturally occurring inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase, is disclosed. The route features a sequential samarium-mediated radical cyclization–fragmentation of an indanone derivative, which provides rapid access to a 10-membered carbocyclic motif fused to an aromatic ring.
创建时间：
2016-02-16
