Untranslated mRNA regions(UTRs) are key mediators of post-transcriptional regulation. Previous studies have predicted thousands of ORFs in 5'UTRs, the vast majority of which have unknown function. We

NIAID Data Ecosystem10

MORFEEdb, a comprehensive catalog of SNVs affecting upstream ORFs in human 5'UTRs

非编码区变异功能注释

上游开放阅读框调控

MORFEEdb is a database containing all possible single nucleotide variants (SNVs) creating or altering upORFs(upORF-SNVs). MORFEEdb was obtained by first performing a mutational saturation of the 5

NIAID Data Ecosystem00

Initiation of translation by non-AUG codons in human T-cell lymphotropic virus type I mRNA encoding both Rex and Tax regulatory proteins

病毒翻译调控

非AUG翻译起始

Human T-cell lymphotropic virus type I (HTLV-I) double-spliced mRNA exhibits two GUG and two CUG codons upstream to, and in frame with, the sequences encoding Rex and Tax regulatory proteins, respecti

PubMed Central2000-04-01 更新10

Competition between translation initiation factor eIF5 and its mimic protein 5MP determines non-AUG initiation rate genome-wide

翻译起始调控

非AUG翻译起始

The goal of this study is to evaluate the competition between eIF5 and 5MP in utilizing non-AUG translation initiation sites Overall design: Investigating the role of eIF5 and 5MP in controlling trans

NIAID Data Ecosystem10

uORF-connected transcripts encoding proteins with a non-AUG start codon.

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