官方服务：
资源简介：
How Impaired PP2A methylation influence physiology and global gene expression.
应用场景：
创建时间：
2022-07-04
相关数据集
Circumventing Embryonic Lethality with Lcmt1 Deficiency: Generation of Hypomorphic Lcmt1 Mice with Reduced Protein Phosphatase 2A Methyltransferase Expression and Defects in Insulin Signaling
Protein phosphatase 2A (PP2A), the major serine/threonine phosphatase in eukaryotic cells, is a heterotrimeric protein composed of structural, catalytic, and targeting subunits. PP2A assembly is gover
NIAID Data Ecosystem40
A specific protein carboxyl methylesterase that demethylates phosphoprotein phosphatase 2A in bovine brain.
Phosphoprotein phosphatase 2A (PP2A) is one of the four major protein serine/threonine phosphatases found in all eukaryotic cells. We have shown that the 36-kDa catalytic subunit of PP2A is carboxyl m
PubMed Central1996-06-11 更新00
Mechanisms of the Scaffold Subunit in Facilitating Protein Phosphatase 2A Methylation
The function of the biologically essential protein phosphatase 2A (PP2A) relies on formation of diverse heterotrimeric holoenzymes, which involves stable association between PP2A scaffold (A) and cata
Figshare2016-01-18 更新00
Loss of LCMT1 and biased protein phosphatase 2A heterotrimerization drive prostate cancer progression and therapy resistance. Loss of LCMT1 and biased protein phosphatase 2A heterotrimerization drive prostate cancer progression and therapy resistance
The first line of therapy for advanced prostate cancer (PCa) is androgen-deprivation therapy (ADT) through surgical or chemical castration; however, in the majority of cases, tumors relapse in a hormo
NIAID Data Ecosystem10
Carboxy-Methylation of PP2Ac Integrates Methionine Availability with Cancer Cell Proliferation
Cancer cells exhibit a well-documented, yet poorly understood, dependence on exogenous methionine, despite retaining the capacity to convert homocysteine to methionine. In contrast, non-tumorigenic ce
NIAID Data Ecosystem00
